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Which of the following statements is not correct?

1. The proinsulin has an extra peptide called C-peptide.
2. The functional insulin has A and B chains linked together by hydrogen bonds.
3. Genetically engineered insulin is produced in E.coli.
4. In man insulin is synthesised as a proinsulin.

Correct answer: The functional insulin has A and B chains linked together by hydrogen bonds.

Solution

The incorrect statement is the one about hydrogen bonds: mature insulin’s A and B chains are linked by disulfide bonds, not hydrogen bonds. The other statements are correct: proinsulin contains C-peptide, human insulin is first made as proinsulin, and recombinant insulin can be produced in E. coli.

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