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The genetic defect - Adenosine deaminase (ADA) deficiency may be cured permanently by:

1. administering adenosine deaminase activators.
2. introducing bone marrow cells producing ADA into cells at early embryonic stages.
3. enzyme replacement therapy.
4. periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.

Correct answer: introducing bone marrow cells producing ADA into cells at early embryonic stages.

Solution

ADA deficiency is a genetic disorder, so a durable cure requires replacing the defective hematopoietic system with cells that can continuously produce ADA. Temporary measures like enzyme replacement or infusing engineered lymphocytes do not permanently correct the underlying defect.

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