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What triggers activation of protoxin to active Bt toxin of Bacillus thuringiensis in boll worm?

1. Body temperature
2. Moist surface of midgut
3. Alkaline pH of gut
4. Acidic pH of stomach

Correct answer: Alkaline pH of gut

Solution

Bt protoxin is activated in the insect midgut because the gut is strongly alkaline, which dissolves the crystal and allows proteolytic processing into the active toxin. Boll worm larvae have this alkaline gut environment, not an acidic stomach like mammals.

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