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Which of the following statements regarding enzyme inhibition is correct?

1. Competitive inhibition is seen when a substrate competes with an enzyme for binding to an inhibitor protein.
2. Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme.
3. Non-competitive inhibition of an enzyme can be overcome by adding large amount of substrate.
4. Non-competitive inhibitors often bind to the enzyme irreversibly.

Correct answer: Competitive inhibition is seen when the substrate and the inhibitor compete for the active site on the enzyme.

Solution

Competitive inhibition occurs when the inhibitor resembles the substrate enough to bind the enzyme’s active site, preventing substrate binding. This matches the statement that the substrate and inhibitor compete for the active site on the enzyme.

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