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Select the option which is not correct with respect to enzyme action

1. Substrate binds with enzyme at its active site.
2. Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.
3. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate.
4. Malonate is a competitive inhibitor of succinic dehydrogenase.

Correct answer: Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate.

Solution

Malonate is a competitive inhibitor of succinate dehydrogenase, so adding more succinate can outcompete it and reduce inhibition. Therefore the statement saying a lot of succinate does not reverse malonate’s inhibition is incorrect.

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