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ExamsNEETChemistry

Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is:

  1. (a) CH₃COOCH₃
  2. (b) CH₃CONH₂
  3. (c) CH₃COOCOCH₃
  4. (d) CH₃COCl

Correct answer: (d) CH₃COCl

Solution

Acyl chlorides (CH₃COCl) are the most reactive towards nucleophilic attack due to the strong electron-withdrawing effect of the chlorine atom, which increases the electrophilicity of the carbonyl carbon.

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