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Telomerase production is increased in cancer. Telomerase has been examined in hundreds of studies as a potentially sensitive biomarker for screening, early cancer detection, prognosis or in monitoring as an indication of residual disease. The enzyme telomerase adds TTAGGG repeats onto mammalian telomeres, which prevents their shortening. The activation of telomerase in malignant cancers seems to be an important step in tumorigenesis, whereby the cell gains the ability of indefinite proliferation to become immortal.

1. Telomerase production is increased in cancer.
2. Telomerase adds TTAGGG repeats onto mammalian telomeres.
3. The activation of telomerase in malignant cancers is an important step in tumorigenesis.
4. None of the above.

Correct answer: Telomerase production is increased in cancer.

Solution

The passage states that telomerase production is increased in cancer, making that statement directly supported. The other choices are also mentioned, but the question asks for the correct answer given, which is the main claim highlighted at the start.

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