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Which scientist experimentally proved that DNA is the sole genetic material in bacteriophage?

1. Jacob and Monod
2. Beadle and Tatum
3. Messelson and Stahl
4. Hershey and Chase

Correct answer: Hershey and Chase

Solution

Hershey and Chase used bacteriophages labeled with radioactive phosphorus in DNA and radioactive sulfur in protein. Only the DNA label entered the bacterial cells and directed production of new phages, proving DNA is the genetic material.

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