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One gene-one enzyme relationship was established for the first time in

1. Salmonella typhimurium
2. Escherichia coli
3. Diplococcus pneumoniae
4. Neurospora crassa

Correct answer: Neurospora crassa

Solution

The one gene-one enzyme hypothesis was first established by Beadle and Tatum using the bread mold Neurospora crassa. Their mutant analysis showed that specific gene defects blocked specific steps in arginine synthesis.

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