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Semi-conservative replication of DNA was first demonstrated in:

1. Escherichia coli
2. Streptococcus pneumoniae
3. Salmonella typhimurium
4. Drosophila melanogaster

Correct answer: Escherichia coli

Solution

Semi-conservative DNA replication was first demonstrated by Meselson and Stahl using Escherichia coli. Their density-gradient experiment showed that each daughter DNA molecule contains one old strand and one newly synthesized strand.

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