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Whose experiments cracked the DNA and discovered unequivocally that a genetic code is a ‘triplet’?

1. Hershey and Chase
2. Morgan and Sturtevant
3. Beadle and Tatum
4. Nirenberg and Matthaei

Correct answer: Nirenberg and Matthaei

Solution

Nirenberg and Matthaei used a cell-free translation system with synthetic RNA, showing that a repeating RNA sequence directed the production of a specific polypeptide. Their work provided direct evidence that the genetic code is read in triplets.

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