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During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure, what is it’s DNA-binding sequence?
- AATT
- CACC
- TATA
- TTAA
Correct answer: TATA
Solution
The promoter region often contains a TATA box, an AT-rich DNA sequence that helps RNA polymerase holoenzyme bind and correctly initiate transcription. Among the options, TATA is the canonical promoter-binding sequence.
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