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The length of DNA molecule greatly exceeds the dimensions of the nucleus in eukaryotic cells. How is this DNA accommodated?

1. super-coiling in nucleosomes
2. DNase digestion
3. through elimination of repetitive DNA
4. deletion of non-essential genes

Correct answer: super-coiling in nucleosomes

Solution

Eukaryotic DNA is packaged by winding around histone proteins to form nucleosomes, which creates higher-order coiling and compaction. This super-coiling allows the very long DNA molecule to fit inside the nucleus.

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