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Anesthetics reduce pain by blocking the transmission of nerve impulses. The kind of chemicals working as anesthetics are those that block

1. only the voltage-gated sodium channels in membranes
2. only the voltage-gated potassium channels in membranes
3. only the neuro-transmitter receptors
4. voltage-gated sodium and potassium channels and neuro-transmitter receptors

Correct answer: only the voltage-gated sodium channels in membranes

Solution

Local anesthetics prevent neurons from generating and conducting action potentials by blocking voltage-gated sodium channels. Without sodium influx, the nerve impulse cannot propagate, so pain transmission is interrupted.

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