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Which of the following substances, if introduced into the blood stream, would cause coagulation of blood at the site of its introduction?

1. Prothrombin
2. Fibrinogen
3. Thromboplastin
4. Heparin

Correct answer: Thromboplastin

Solution

Thromboplastin (tissue factor) initiates the coagulation cascade, leading to thrombin formation and then fibrin clot formation at the site of introduction. Prothrombin and fibrinogen are clotting precursors, while heparin inhibits coagulation.

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