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Adult human RBCs are enucleated. Which of the following statement(s) is/are most appropriate explanation for this feature? (1) They do not need to reproduce (2) They are somatic cells (3) They do not metabolize (4) All their internal space is available for oxygen transport

1. (a) only (1).
2. (b) (1), (3) and (4).
3. (c) (2) and (3).
4. (d) only (4).

Correct answer: (d) only (4).

Solution

Adult RBCs lack a nucleus mainly to maximize internal space for hemoglobin, improving oxygen transport. The other statements are not valid explanations: RBCs do not reproduce, but that alone does not explain enucleation; they are somatic cells, and they do metabolize via glycolysis.

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