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When you hold your breath, which of the following gas changes in blood would first lead to the urge to breathe?
- rising CO2 concentration
- falling CO2 concentration
- rising CO2 and falling O2 concentration
- falling O2 concentration
Correct answer: rising CO2 concentration
Solution
During breath-holding, carbon dioxide builds up in the blood quickly because it is continuously produced by metabolism. Central chemoreceptors are especially sensitive to this rise, which triggers the urge to breathe before oxygen falls enough to be the main stimulus.
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