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Bulk of carbon dioxide (CO₂) released from body tissues into the blood is present as

1. bicarbonate in blood plasma and RBCs
2. free CO₂ in blood plasma
3. 70% carbamino-haemoglobin and 30% as bicarbonate
4. carbamino-haemoglobin in RBCs

Correct answer: bicarbonate in blood plasma and RBCs

Solution

Most CO₂ entering blood from tissues is converted in RBCs to carbonic acid and then to bicarbonate, which is the major transport form. Bicarbonate is carried in both plasma and RBCs, while only a small fraction remains dissolved or bound to hemoglobin.

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