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All enzymes of TCA cycle are located in the mitochondrial matrix except one which is located in inner mitochondrial membranes in eukaryotes and in cytosol in prokaryotes. This enzyme is

1. isocitrate dehydrogenase
2. malate dehydrogenase
3. succinate dehydrogenase
4. lactate dehydrogenase

Correct answer: succinate dehydrogenase

Solution

Succinate dehydrogenase is unique because it functions in both the TCA cycle and the respiratory chain. In eukaryotes it is bound to the inner mitochondrial membrane, while in prokaryotes it is associated with the cytosolic membrane region.

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