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Conversion of glucose to glucose-6-phosphate, the first irreversible reaction of glycolysis, is catalysed by:

1. Aldolase
2. Hexokinase
3. Enolase
4. Phosphofructokinase

Correct answer: Hexokinase

Solution

Hexokinase catalyzes the phosphorylation of glucose to glucose-6-phosphate, which is the first irreversible step of glycolysis. This reaction uses ATP and helps trap glucose inside the cell for further metabolism.

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