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In RNAi, the genes are silenced using:

1. ds - DNA
2. ds - RNA
3. ss - DNA
4. ss - RNA

Correct answer: ds - RNA

Solution

RNAi is initiated by double-stranded RNA, which is recognized and cut into small interfering RNAs that guide silencing of complementary mRNA. Single-stranded DNA or RNA does not serve as the classic trigger for this pathway.

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