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The association of histone H1 with a nucleosome indicates:

1. DNA replication is occurring.
2. The DNA is condensed into a Chromatin Fibre.
3. The DNA double helix is exposed.
4. Transcription is occurring.

Correct answer: The DNA is condensed into a Chromatin Fibre.

Solution

Histone H1 binds to the linker DNA between nucleosomes and promotes tighter folding of chromatin. Its association is a sign that DNA is in a more condensed chromatin fibre state, not exposed for transcription or replication.

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