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What is the absolute configuration of the compound represented below? CO2H | H — C — OH | H — C — Cl | CH3

1. (2S, 3S)
2. (2R, 3R)
3. (2R, 3S)
4. (2S, 3R)

Correct answer: (2R, 3S)

Solution

The correct option (2R, 3S) indicates that at carbon 2, the highest priority substituent is the carboxylic acid (CO2H), which gives it an 'R' configuration, while at carbon 3, the chlorine (Cl) takes priority over the hydroxyl (OH) and methyl (CH3) groups, resulting in an 'S' configuration.

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