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Sanger's reagent, 2,4-dinitrofluorobenzene, interacts with the amino group (-NH2) of a peptide and produces a 2,4-dinitrophenyl (DNP) derivative. Hydrolysis of this derivative results in the formation of a DNP derivative of one amino acid. Which statement is accurate?

1. 2,4-Dinitrofluorobenzene interacts with the amino group (-NH2) of the peptide.
2. A 2,4-dinitrophenyl (DNP) derivative of the peptide is formed.
3. Hydrolysis of the DNP derivative yields a DNP derivative of a single amino acid.
4. None of these statements are correct.

Correct answer: Hydrolysis of the DNP derivative yields a DNP derivative of a single amino acid.

Solution

The DNP derivative of the peptide is hydrolyzed to yield the DNP derivative of a single amino acid, which is a key step in identifying the N-terminal amino acid of a peptide.

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