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Which of the following correctly represents the sequence of events during mitosis?

1. (a) The sequence of events in mitosis is as follows: (i) Chromosomes become visible due to DNA condensation in early to mid-prophase. (ii) Breakdown of the nuclear envelope starts in late prophase or the metaphase transition. (iii) Chromosomes align at the cell's equatorial plane during metaphase. (iv) Division of centromeres occurs in anaphase, creating daughter chromosomes. (v) Daughter chromosomes are pulled to opposite poles during anaphase. (vi) Telophase results in the formation of two nuclei in daughter cells.
2. (b) Anaphase Promoting Complex (APC) is a protein required for separating daughter chromosomes during anaphase. A defective APC prevents chromosome segregation at this stage.
3. (c) Kinetochores facilitate the attachment of microtubules to chromosomes and monitor spindle assembly, ensuring anaphase does not begin prematurely during mitosis.
4. (d) Synapsis refers to the pairing of homologous chromosomes during meiosis, specifically in prophase I, allowing for homologous pairing and potential crossover.

Correct answer: (a) The sequence of events in mitosis is as follows: (i) Chromosomes become visible due to DNA condensation in early to mid-prophase. (ii) Breakdown of the nuclear envelope starts in late prophase or the metaphase transition. (iii) Chromosomes align at the cell's equatorial plane during metaphase. (iv) Division of centromeres occurs in anaphase, creating daughter chromosomes. (v) Daughter chromosomes are pulled to opposite poles during anaphase. (vi) Telophase results in the formation of two nuclei in daughter cells.

Solution

Option (a) correctly lists the canonical sequence of mitosis from chromosome condensation through nuclear re-formation. The other choices describe related cell-cycle structures or meiosis, not the full mitotic event order.

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