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Obstacle to large scale transplantation of organs is

1. insufficiency of organ donors
2. immunological rejection of foreign bodies
3. religious or ethnic considerations
4. lack of effective surgical techniques

Correct answer: immunological rejection of foreign bodies

Solution

Transplanted organs often carry foreign antigens, so the recipient's immune system can attack and destroy them. This immunological rejection is the major biological obstacle to successful large-scale transplantation.

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