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Which of the following immune responses is responsible for rejection of kidney graft?

1. Auto-immune response
2. Humoral immune response
3. Inflammatory immune response
4. Cell-mediated immune response

Correct answer: Cell-mediated immune response

Solution

Kidney graft rejection is primarily caused by T lymphocytes attacking donor antigens, especially foreign MHC molecules. This is a classic cell-mediated immune response rather than an antibody-only or nonspecific inflammatory process.

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