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In higher vertebrates, the immune system can distinguish self-cells and non-self. If this property is lost due to genetic abnormality and it attacks self-cells, then it leads to

1. allergic response
2. graft rejection
3. auto-immune disease
4. active immunity

Correct answer: auto-immune disease

Solution

When the immune system can no longer distinguish self from non-self, it begins attacking the body's own tissues. That condition is called an autoimmune disease.

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