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It is not possible to apply Koch's postulates to

1. Diphtheria
2. Cholera
3. Leprosy
4. Tuberculosis

Correct answer: Leprosy

Solution

Koch’s postulates require the pathogen to be isolated and grown in pure culture, then shown to cause disease. The leprosy bacillus cannot be routinely cultured in artificial media, so the postulates cannot be fully applied to it.

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