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One gene -one enzyme hypothesis was postulated by

1. Hershey and Chase
2. A. Garrod
3. Beadle and Tatum
4. R. Franklin

Correct answer: Beadle and Tatum

Solution

Beadle and Tatum proposed the one gene–one enzyme hypothesis after studying nutritional mutants of Neurospora. Their experiments showed that mutations in single genes could block specific enzymatic steps in a metabolic pathway.

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