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Thalassemia is a quantitative problem of synthesising very few globin molecules while sickle cell anaemia is a qualitative problem of synthesising an incorrectly functioning globin.

1. Sickle cell anaemia
2. Thalassemia
3. Down’s syndrome
4. Haemophilia

Correct answer: Thalassemia

Solution

Thalassemia is a quantitative defect because the globin chains are produced in reduced amounts. Sickle cell anaemia is qualitative because the globin is made, but its amino acid change causes abnormal function.

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