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Of a normal couple, half the sons are haemophilic while half the daughters are carriers. The gene is located on

1. X-chromosome of father
2. Y-chromosome of father
3. one X-chromosome of mother
4. both the X-chromosomes of mother

Correct answer: one X-chromosome of mother

Solution

If half the sons are haemophilic and half the daughters are carriers, the mother must be heterozygous for an X-linked recessive allele. Sons receive their only X from the mother, so half are affected; daughters receive one normal X from the father and may inherit the mutant X from the mother, making half carriers.

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