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Which of the following is an example of pleiotropic effect?

1. Haemophilia
2. Thalassemia
3. Sickle cell anaemia
4. Colour blindness

Correct answer: Sickle cell anaemia

Solution

Sickle cell anaemia is pleiotropic because one mutation in the beta-globin gene produces several effects, including abnormal red blood cell shape, anaemia, pain crises, and altered malaria susceptibility. The other options are mainly examples of single-trait genetic disorders.

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