Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino?

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Accepted Answer

25%. Since albinism is autosomal recessive and the parents are phenotypically normal, having an albino child means both parents must be carriers (Aa). Each pregnancy is independent, and an Aa × Aa cross gives a 1/4 chance of an affected child (aa).

Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino?

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