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Sickle cell anaemia is induced by

1. change of amino acid in a-chain of haemoglobin
2. change of amino acid in b-chain of haemoglobin
3. change of amino acid in both a- and b-chain of haemoglobin
4. change of amino acid in either a- or b-chain of haemoglobin

Correct answer: change of amino acid in b-chain of haemoglobin

Solution

Sickle cell anaemia is caused by a point mutation in the beta-globin gene, producing hemoglobin S. This changes one amino acid in the b-chain of haemoglobin, which promotes polymerization under low oxygen and leads to sickling.

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