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Sickle cell anaemia is:

1. caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
2. caused by a change in a single base pair of DNA
3. characterized by elongated sickle like RBCs with a nucleus
4. an autosomal linked dominant trait

Correct answer: caused by a change in a single base pair of DNA

Solution

Sickle cell anaemia is caused by a single base substitution in the beta-globin gene, which changes the amino acid sequence of hemoglobin. This is a classic point mutation, not a dominant trait and not a change involving a nucleus in RBCs.

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