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Haemophilia is more commonly seen in human males than in human females because:

1. a greater proportion of girls die in infancy
2. this disease is due to a Y-linked recessive mutation
3. this disease is due to an X-linked recessive mutation
4. this disease is due to an X-linked dominant mutation

Correct answer: this disease is due to an X-linked recessive mutation

Solution

Haemophilia is inherited as an X-linked recessive trait. Males have one X and one Y, so a single recessive mutation on their X chromosome is enough to cause the disease, while females usually need two copies to be affected.

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