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Cri-du-chat syndrome in humans is caused by the:

1. loss of half of the short arm of chromosome 5
2. loss of half of the long arm of chromosome 5
3. trisomy of 21st chromosome
4. fertilization of an XX egg by a normal Y-bearing sperm

Correct answer: loss of half of the short arm of chromosome 5

Solution

Cri-du-chat syndrome is caused by a deletion on the short arm (p arm) of chromosome 5, often written as 5p deletion. This loss of genetic material produces the characteristic symptoms, including the high-pitched cry in infants.

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