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Which one of the following conditions in humans is correctly matched with its chromosomal abnormality/linkage?

1. Klinefelter's syndrome-44 autosomes + XXY
2. Colour blindness - Y-linked
3. Erythroblastosis foetalis - X-linked
4. Down's syndrome - 44 autosomes + XO

Correct answer: Klinefelter's syndrome-44 autosomes + XXY

Solution

Klinefelter's syndrome is caused by an extra X chromosome in a male, giving the karyotype 44 autosomes + XXY. The other options mismatch the known inheritance patterns or chromosomal abnormalities.

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