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Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement:

1. Both are due to a quantitative defect in globin chain synthesis
2. Thalassemia is due to less synthesis of globin molecules
3. Sickle cell anemia is due to a quantitative problem of globin molecules
4. Both are due to a qualitative defect in globin chain synthesis

Correct answer: Thalassemia is due to less synthesis of globin molecules

Solution

Thalassemia is a quantitative defect because globin chains are produced in reduced amounts. Sickle cell anemia is a qualitative defect because the globin chain is structurally abnormal due to a mutation.

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