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Which one pair of the following parents is most likely to get a child who suffer from hemolytic disease of the new born?

1. Rh-negative mother and Rh-positive father
2. Rh-positive mother and Rh-negative father
3. Rh-negative mother and Rh-negative father
4. Rh-positive mother and Rh-positive father

Correct answer: Rh-negative mother and Rh-positive father

Solution

Hemolytic disease of the newborn is most likely when an Rh-negative mother carries an Rh-positive fetus, because fetal Rh antigen can trigger maternal antibody formation. An Rh-positive father can pass the Rh factor to the child, making this mismatch possible.

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