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Toxic agents present in food which interfere with thyroxine synthesis lead to the development of:

1. toxic goitre
2. cretinism
3. simple goitre
4. thyrotoxicosis

Correct answer: simple goitre

Solution

Agents in food that interfere with thyroxine synthesis reduce thyroid hormone production. The pituitary responds by increasing TSH, which stimulates thyroid enlargement, producing a simple goitre rather than hyperthyroidism or cretinism.

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