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Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (Mostly in the nucleus)?

1. Insulin, glucagon
2. Thyroxin, insulin
3. Somatostatin, oxytocin
4. Cortisol, testosterone

Correct answer: Cortisol, testosterone

Solution

Cortisol and testosterone are steroid hormones, so they are lipid-soluble and can cross the target cell membrane to bind intracellular receptors, often in the nucleus. Insulin, glucagon, somatostatin, and oxytocin are peptide hormones and generally act through membrane receptors.

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