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Changes in GnRH pulse frequency in females is controlled by circulating levels of:

1. (a) estrogen and progesterone
2. (b) estrogen and inhibin
3. (c) progesterone only
4. (d) progesterone and inhibin

Correct answer: (a) estrogen and progesterone

Solution

GnRH pulse frequency in females is regulated mainly by circulating ovarian steroids. Estrogen and progesterone provide feedback to the hypothalamus and pituitary, with progesterone especially slowing pulse frequency and estrogen modulating feedback across the cycle.

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