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ExamsNEETBiology

Alzheimer disease in humans is associated with the deficiency of acetylcholine. Acetylcholine is the neurotransmitter produced by neurons referred to as cholinergic neurons. Acetylcholine plays a role in skeletal muscle movement, as well as in the regulation of smooth muscle and cardiac muscle. Acetylcholine is synthesised from choline and acetyl coenzyme-A through the action of the enzyme choline acetyltransferase and becomes packaged into membrane-bound vesicles.

  1. Alzheimer disease is associated with the deficiency of dopamine.
  2. Alzheimer disease is associated with the deficiency of serotonin.
  3. Alzheimer disease is associated with the deficiency of acetylcholine.
  4. Alzheimer disease is associated with the deficiency of norepinephrine.

Correct answer: Alzheimer disease is associated with the deficiency of acetylcholine.

Solution

Alzheimer disease is classically linked to reduced acetylcholine signaling, especially in pathways important for memory and cognition. The other options name different neurotransmitters that are not the primary association here.

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