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Calcium is important in skeletal muscle contraction because it

1. Binds to troponin to remove the masking of active sites on actin for myosin.
2. Activates the myosin ATPase by binding to it.
3. Prevents the formation of bonds between the myosin cross bridges and the actin filament.
4. Detaches the myosin head from the actin filament.

Correct answer: Binds to troponin to remove the masking of active sites on actin for myosin.

Solution

Calcium binds to troponin, which shifts tropomyosin away from actin’s myosin-binding sites. This exposes the active sites so myosin can form cross-bridges and contraction can proceed.

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