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The active molecule that helps initiate the inflammatory response when mast cells degranulate is:

1. perforin
2. histamine
3. heparin
4. insulin

Correct answer: histamine

Solution

Mast cells degranulate and release histamine, which rapidly triggers inflammation by increasing vascular permeability and causing vasodilation. Perforin is used by cytotoxic cells, heparin is an anticoagulant, and insulin is a metabolic hormone.

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