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Examination of blood of a person suspected of having anaemia, shows large, immature, nucleated erythrocytes without haemoglobin. Supplementing his diet with which of the following, is likely to alleviate his symptoms?

1. Folic acid and cobalamine
2. Riboflavin
3. Iron compounds
4. Thiamine

Correct answer: Folic acid and cobalamine

Solution

Folic acid and cobalamin are required for DNA synthesis in rapidly dividing marrow cells. Their deficiency causes megaloblastic anemia with large, immature, nucleated erythrocytes and poor hemoglobinization.

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