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What will happen if the secretion of parietal cells of gastric glands is blocked with an inhibitor?

1. Gastric juice will be deficient in chymosin
2. Gastric juice will be deficient in pepsinogen
3. In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin
4. Enterokinase will not be released from the duodenal mucosa and so trypsinogen is not converted to trypsin

Correct answer: In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin

Solution

Parietal cells secrete hydrochloric acid, which creates the acidic environment needed to activate pepsinogen into pepsin. If acid secretion is blocked, pepsinogen remains inactive, so protein digestion in the stomach is impaired.

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