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During mitosis ER and nucleolus begin to disappear at:

1. late prophase
2. early metaphase
3. late metaphase
4. early prophase

Correct answer: late prophase

Solution

In late prophase, the nucleolus disappears and the endoplasmic reticulum/nuclear membrane breakdown begins as the cell prepares for metaphase. This is the transition point where the nucleus is no longer intact.

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